Cbd Oil For Autism And Epilepsy
Did you know that less than 2% of the general population has epilepsy, but up to 33% of people with autism also suffer from epilepsy? While scientists do not clearly understand the reasons behind the relationship, they suspect that the different brain development that occurs in autistic children is more likely to create circuits that cause epileptic seizures.
Earlier this year, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to treat two rare forms of childhood epilepsy, Dravet Syndrome and Lennox-Gastaut Syndrome. These two conditions have early onset in childhood and present with seizures that are difficult to control.
The syndromes have impacts that grossly affect the childs development and overall quality of life. This news is huge for the medical and autism community; as this is the first time the FDA has approved a marijuana-derived substance.
How Do You Choose Which Cbd Oil To Use
There are so many brands of CBD oil to choose from. There are also many “snake oils” on the market, so it’s important to do your research. Find out the source of the CBD, where it’s grown and how it’s processed. You should check third-party testing results provided by CBD Oil companies.
If a company can’t provide you with a third-party lab test or a certificate of authentication , then we would recommend finding another brand.
What Are The Risks Of Using Cbd Oil For Autism
Studies suggest it is perfectly safe to administer to children; however, some side effects to watch for include:
- Anxiety and depression
For most children, the health benefits of outweigh the side effects. As with any medication, always seek the advice of a physician with any questions you may have regarding treatment and your childs medical condition; never disregard professional medical advice or delay in seeking it.
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Evaluation Of The Results
Patients were followed by means of periodic clinical evaluations made by the physician in charge. A monthly questionnaire was used to record treatment effects based on the answers given by the parents. Monthly standardized forms were filled out and contained questions covering the following symptom categories :
Attention Deficit/Hyperactivity Disorder ;
Communication and Social Interaction Deficits ;
Cognitive Deficits ;
Sleep Disorders ;
Parents answered the initial questionnaires in August 2016 to assess the presence or absence of these symptoms before the onset of CE treatment. In the monthly questionnaires that followed for the next 9 months, until April 2017, the perceived percentage change for each symptom category was assessed. Clinical assessments and monthly records also included information regarding side effects and changes, maintenance, reduction, or withdrawal of neuropsychiatric drugs that were already in use .
The descriptive statistics in were plotted in MATLAB 2017a using the default settings of the boxplot function from the Statistics and Machine Learning Toolbox.
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Fmri Pattern After Using Cbd
It was noticed that CBD and CBDV altered the GABAergic system in all participants. The excitatory mechanisms of response to glutamate did not differ between the two groups, however the inhibitory response mediated by GABA was different in people with ASD, indicating that the brain of an autistic individual has a distinct GABAergic system from that of neurotypical individuals. In other words, the autistic brain reacts differently to GABA, and this discovery may help understand the mechanisms and targets of treatment in autism. Pretzsch et al.2828. Pretzsch CM, Voinescu B, Mendez MA, Wichers R, Ajram L, Ivin G, et al. The effect of cannabidiol on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder . J Psychopharmacol. 2019;33:1141-8. were pioneers for publishing the first evidence of neuromodulation made from the administration of CBD in fractional amplitude of low-frequency fluctuations and connectivity function in the brains of adults with ASD.
Important Safety Considerations Of Cbd And Autism
CBD is generally well-tolerated across demographics, but most studies report a small percentage of exclusions related to adverse effects.
These effects most commonly include
- Low blood pressure
CBD doesnt have synergistic interactions with drugs, meaning it doesnt aggressively and harmfully interact with medications like alcohol does, but it still affects drug metabolism in many instances.;
The greater concern for most parents considering CBD for their autistic children is not the low possibility of side effects, but the reliability and purity of the product.
Since CBD is almost completely unregulated , producers arent required to meet FDA standards.
This lack of oversight has allowed unscrupulous brands to cut corners with their formulations, sometimes resulting in high-THC or otherwise impure CBD products.
Thankfully, consumers now have unfettered access to more than just reviews of the best brands; we can see exactly what is in a particular brands product by accessing third-party lab results.
If no third-party lab results exist, thats strike one, two, and three.
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Results Grouped By Symptom Categories
Clinical assessment and records of patients’ evolution, which were filled in monthly by the patients’ guardians/caretakers, targeted the main symptom categories associated with autism. Possible side effects of CE administration and modifications in the dosage of other neuropsychiatric drugs that were prescribed were also evaluated and are presented in . From the 15 patients who adhered to the treatment with standardized EC, 15 had symptoms of ADHD; 15 of BD; 12 of MD; 15 of AD; 15 of CSID; 15 of CD; 12 of SD; and 5 of SZ. Also, as shown in , 10 of these patients were also concomitantly taking other prescribed neuropsychiatric medications .
Can Cbd Help With Autism
Cannabidiol is one of the main cannabinoids in the cannabis plant. The benefit of CBD is that its non-psychotropic. It doesnt cause the high sensation that people often associate with cannabis.
CBD interacts with the endocannabinoid system, the cannabinoid receptors , and other receptors in the human body. These receptors are the ones that work with the neurotransmitters, usually manipulated when treating behavioural issues that are secondary to Autism. CBD is also known to help treat anxiety and agitation which individuals with Autism often display.
CBD can also affect receptors outside of the endocannabinoid system that are important for mood and behaviour. The activation of these receptors can affect the neurotransmitters that are:
For example, CBD affects serotonergic receptors. CBD can activate the receptors and mimic what some anxiolytic medications do.
CBD also affects the dopaminergic receptors, the dopamine receptors. These receptors are often affected by psychotic medication. So, its in this way that CBD can affect agitation and aggression.
There was also a study on children on the Autistic spectrum, which showed a lower concentration of endocannabinoids in their blood than neurotypical children.
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Improvements In Quality Of Life
The study also looked at the benefits of the use of cannabis and autism quality of life improvements. Quality of life, mood and ability to perform activities of daily living were assessed prior to treatment and at six months. Good quality of life was reported by 31.3% of patients prior to treatment initiation. At six months, good quality of life more than doubled to 66.8%. Positive mood was reported as 42% before treatment and 63.5% after six months.
Other aspects of independence and quality of life were assessed such as the ability to dress and shower independently. This improved significantly from cannabis treatment. Only a quarter reported no difficulty prior to the treatment while 42.9% improved their ability to dress and shower independently at six months.
The study also showed that cannabis oil medication was able to significantly improve sleep and concentration. Good sleep and concentration were reported by 3.3% and 0% respectively at the outset, compared to 24.7% and 14% during an active treatment.
Dr Victor Novack, of the BGU-Soroka Clinical Cannabis Research Institute, said: While this study suggest that cannabis treatment is safe and can improve ASD symptoms and improve ASD patients quality of life, we believe that double blind placebo-controlled trials are crucial for a better understanding of the cannabis effect on ASD patients.
How To Take Cbd Oil For Autism
CBD oils are the most popular cannabidiol products that are purchased today. These are often available in the form of tinctures with a standard dropper to measure doses accurately.
Some CBD products may be found as tablets or as capsules, which can be taken just like a dietary supplement. Others are sold as chewable gummies and edibles in the form of CBD cookies.
Retailers can also include CBD for vaping using vape pens and are available in a range of flavors.
The variety of choices present when it comes to CBD products allows buyers to select the most appropriate format of administering CBD to their ASD patients.
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How To Use Cbd Oil
There are many ways to consume CBD.;According to Healthcare Weekly, CBD oil is best served for people who want to feel the effects quickly or dont like taking pills or capsules.
If its your first time using CBD oil, start with the lowest dosage. Then, gradually increase it if you dont feel the effects. In fact, some disorders benefit more from lower doses of CBD.
Take a couple of drops under your tongue and let them sit there for around 60 seconds, then swallow. It shouldnt be long until you feel the effects. If you dont, then up the dosage to another drop or two the next time, you use it. Repeat the process until you find your level.
Remember, everyone is different, so what works for you may not work for someone else. Many factors impact optimal dosage, such as age, height, weight, activity levels, etc.
As mentioned in the previous section, make sure you make notes of any noticeable changes. This allows you to review your records to see CBDs helpful on stress levels, behavioral issues, etc.
Cannabis And Autism Behavioural Improvement
Autistic Spectrum Disorder is an extensive developmental disorder that is expressed in almost all dimensions of the childs development. It is now common to refer to this disorder as a wide range of Pervasive Developmental Disorders in which there are various manifestations and symptoms.
BGUs Dr Gal Meiri of the Negev Autism Center, said: We analysed the data prospectively collected as part of the treatment program of 188 ASD patients treated with medical cannabis between 2015 and 2017. The treatment in majority of the patients was based on cannabis oil containing 30% cannabidiol oil and 1.5% tetrahydrocannabinol . Symptoms, patient global assessment and side effects at six months were primary outcomes of interest and were assessed by structured questionnaires.
The study was published in;Scientific Reports and showed that after six months of treatment, 30% of patients reported a significant improvement, 53.7% reported moderate improvement, and only 15% had slight or no change.
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How Cbd May Help People With Autism
Neither CBD nor any other drug can remove or cure core symptoms of autism, which include social communication challenges, sensory dysfunction, and restricted, repetitive behaviors. CBD can, however, help to alleviate disorders often associated with autism such as epilepsy, anxiety, sleeplessness, and stress.
For example, it may cause better sleep and lower anxiety , fewer seizures , and lower anxiety to make it easier to learn and use social communication skills.
It’s also important to note that sleeplessness and aggression are particularly difficult symptoms for parents, who can quickly find themselves exhausted and overwhelmed. Aggression, in particular, is one of the most challenging behaviors common to autismoftentimes, this is a reason a parent may place their child with autism in an institutional setting.
Is It Effective For Autism Andasperger’s
We want to know how CBD oil impacts autism. Is CBD an effective treatment for autism? Is obtaining medical marijuana for autism a good investment of time and resources? And do the benefits outweigh the risks?
There are multiple facets to consider when answering these questions. The simple answer is that there isnt a wealth of research done for pediatric patients with autism there is practically NO study validating the idea that cannabis is an effective and available option for the treatment of autism yet.
Nevertheless, one cant ignore the reports of this miracle drug that has so many proven success stories.
For an individual with autism, a developmental disability with no proven treatment, youre open to many therapies and strategies that might alleviate symptoms. CBD itself has shown promising results as a treatment for a variety of conditions, many of which are otherwise not treatable.
The most well-known properties of CBD are neuroprotective, anticonvulsant, anti-inflammatory and analgesic. CBD also possesses therapeutic value to treat conditions like depression, anxiety, and dependence.
Some reports show a decline in aggressive behavior, a significant decrease in seizures, and improved speech. Some accounts include children who did not speak before treatment who achieved significant results in a short period of time after their first dose of CBD oil.
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Is There A Typical Dosage Of Cannabis For Treating Autism
No. Every individual is different and will need something slightly different, and cannabis doesnt work for everyone.;
Doctors always use the methodology of start low and go slow. Patients will always take a very tiny amount of cannabis and then increase slowly over time to prevent side effects and adverse events.
Particularly with children, I start with the minimal dose possible. Theoretically, you can start with one milligram per kilo of CBD. However, I start much lower than that. Usually, Ill go with the minimal dose recommended by the producer or even lower. For example, if its by drop, I might start a child on one drop either twice or three times a day. Please remember this is not medical advice. Its simply an example everyone is a bit different.
Remember, CBD is considered quite safe in humans, and some studies on epilepsy have used doses up to 50mg/kg.
To give you an idea of how treatment can go, the maximum dose for CBD is 16mg/kg or up to 1g a day, but thats an extremely high dose. Research has been found one gram to be safe for adults .;
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