Agreements And Disagreements With Other Studies Or Reviews
Two previous systematic reviews have assessed the effects of bupropion for adult ADHD. Faraone 2010 estimated effect sizes of different medications for adult ADHD. They included doubleblinded, placebocontrolled studies of ADHD in adults that presented the means and SDs of either change or endpoint scores for intervention and placebo groups. Out of 18 records, they found three studies that evaluated bupropion versus placebo . Whilst they did not provide an estimate of effects for the thee studies of bupropion, they estimated the number needed to treat for an additional beneficial outcome to be approximately 4.5 for bupropion.
Maneeton 2011 aimed to systematically review the efficacy, acceptability, and tolerability of bupropion compared to placebo for adults with ADHD. They included five trials also included in our review and reached similar conclusions. There are some differences between their review and ours in the way that results are included in the analysis. For example, we set higher standards for methodological quality, concluding that for most items reporting was incomplete to make a robust assessment, whereas Maneeton 2011 judged all studies to be at low risk of bias. The authors concluded that evidence suggests that bupropion is effective and safe for adults with ADHD. Although the conclusions are similar to our review, their review lacks any caution with respect to their conclusion due to small studies sizes and poor reporting of study quality.
Medication Chart To Treat Attention Deficit Disorders
This chart was updated 4/19/04.
Treatment of ADHD usually includes medical management, behavior modification. counseling, and school or work accommodations. The medications charted above include: the stimulants, the non-stimulant Strattera with effects similar to stimulants, the antidepressant Wellbutrin and two antihypertensives Catapres and Tenex . Stimulants include all formulations of methyphenidate and all forms of amphetamines . Individuals respond in their own unique way to medication depending upon their physical make-up, severity of symptoms. associated conditions, and other factors. Careful monitoring should be done by a physician in collaboration with the teacher, therapist. parents, spouse, and patient. Medications to treat ADHD and related conditions should only be prescribed by a physician. Information presented here is not intended to replace the advice of a physician.
Important Note: Medications to treat ADHD and related conditions should only be prescribed by a physician. Information presented here is not intended to replace the advice of a physician.
Why Your Doctor May Prefer Wellbutrin To Adderall
A doctor may recommend Wellbutrin to treat ADHD symptoms if:
- You cant tolerate the side effects of stimulant drugs
- Adderall or other stimulant drugs have not been effective in managing your symptoms
- You have a substance abuse disorder or history of addiction
- You have an addiction to nicotine
- You also have other mental health disorders, like depression, along with ADHD
The symptoms above are not an exhaustive list of potential side effects.
If something doesnt feel right, contact your doctor as soon as possible.
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Is There Research To Support Using Wellbutrin For Adhd
There have been several small, randomized clinical trials completed to test how well Wellbutrin works to treat ADHD. All of these studies were done in adults.
In these trials, which included a total of more than 400 people, long-acting forms of Wellbutrin resulted in clinically significant improvements in the symptoms of ADHD. It was also shown to be safe compared to a placebo.
Dosage Recommendation For Narcolepsy
The medication label doesnt recommend Adderall in children under the age of 6 for narcolepsy treatment, and Adderall XR isnt approved for treating narcolepsy.
- Children 6 to 11 years old start on 5 mg once a day. The medical provider may increase the dose by 5 mg each week until the medicine works.
- Children 12 to 17 years old start at 10 mg once a day. The medical provider may increase the dose by 10 mg each week until the medicine works.
- Adults 18 years or older start at 10 mg once a day. The medical provider may increase the dose by 10 mg each week until the medicine works.
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Is There A Non
Dr. Chatigny says brand drugs like Strattera and Wellbutrin are OK options for treating ADHD.
Non-stimulant medications like these and others dont have abuse potential. However, the downside is they typically take longer to work, she says. Amphetamines like Adderall begin to work within 30 minutes to an hour. Non-stimulants like Strattera can take 4 to 8 weeks to reach maximum effectiveness at the proper dose.
Dr. Chatigny prefers a non-stimulant treatment regime for patients with ADHD, especially in adults, because central nervous stimulants like Adderall are controlled substances, meaning theyre regulated by the federal government because they have a high potential for abuse, addiction and physical dependence.
As always, talk to your doctor about Adderall, ADHD, and other medications.
Dr. Chatigny is board-certified in child, adolescent and adult psychiatry, a fellow of the American Psychiatric Association, and is the medical director of behavioral health with Lee Physician Group. Her treatment interests include emergency psychiatry, treatment resistant depression, complex psychopharmacology, and substance use disorders.
Which Is Right For You
When comparing Wellbutrin to Adderall for ADHD, Adderall is the clear winner for most people. If you have ADHD and have not tried either medication, you will generally first be put on a stimulant. The exception is if you have known heart problems, where the doctor will need to more carefully weigh the risks and benefits.
When stimulants are not a good choice for you, or they have proven in some way ineffective, you will then usually be put on nonstimulants. While the name might imply antidepressants fall under this umbrella, nonstimulants refer to a few FDA-approved drugs that are proven to help with ADHD symptoms. They are generally less effective than stimulants but can be a good alternative choice for some people.
Antidepressants are not FDA-approved to treat ADHD. There is still more research that should be done. The existing research suggests drugs like Wellbutrin are simply not as effective as the alternatives in the majority of cases. This is not to say this option is wrong for every patient. Some patients may need an alternative to the FDA-approved options for a variety of legitimate reasons.
All things being equal, it is likely you will want to try Adderall before Wellbutrin. The only exception will be those who have already tried the alternatives or whose doctors decide that traditional treatments pose too much risk.
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Wellbutrin Vs Adderall: Differences And Similarities
Medically reviewed by Katelyn Hagerty, FNP
Anxiety and depression are two common mental conditions its estimated that about 40 million adults deal with anxiety and an estimated 21 million U.S. adults have depression.
Meanwhile, attention-deficit/hyperactivity disorder is one of the most common neurodevelopmental disorders that affects children, and it can last well into adulthood. In 2020, ADHD affected over 360 million adults globally.
If youre one of the many people who has been diagnosed with one of these conditions, you might wonder about the different treatments for each and whether or not any types of treatment can be used for both.
Wellbutrin and Adderall are two common prescription medications used by healthcare providers to treat anxiety and depressive disorders and ADHD, respectively. But can you use either medication for both conditions?
While there are similarities between these two medications, there are also important differences to know. We go into more detail on everything you need to know about Wellbutrin vs Adderall.
Wellbutrin Vs Adderall: Whats The Difference
ADHD affects nearly 4% of adults and 8% of children in the United States.
Adderall is one of the medications of choice for managing the symptoms of ADHD.
However, its not the only medication that is prescribed.
In some cases, patients may not tolerate the stimulant drug and are recommended another medication, like Wellbutrin.
While Wellbutrin is primarily used as a treatment option for depression, it is sometimes recommended to treat some cases of ADHD.
In this article, Ill explain what Wellbutrin is, how it works, and what its used to treat.
Ill talk about how Adderall works and what its used to treat.
Ill then explain the differences between these two medications, especially as it relates to ADHD.
Ill outline some precautions for both medications, and tell you when you should see a doctor or other healthcare professional.
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Switching From Wellbutrin To Adderall
For treating ADHD, Adderall may be a more effective medication than Wellbutrin. If you decide to make the switch, you might notice differences in how you feel. You may experience more of a stimulant effect with Adderall, which can disrupt your sleep, says Aaeedy. Its worth noting that under no circumstances should you stop taking your Wellbutrin abruptly. Your doctor can help you wean down your Wellbutrin dosage before making the switch to Adderall. Stopping bupropion can result in withdrawal symptoms, including irritability, anxiety, sleep disturbances, headaches, and generalized aches and pains, research has shown.
Heart Problems Associated With Adderall And Wellbutrin
Wellbutrin has been linked with high blood pressure, sometimes to emergency levels. While this effect is most prevalent in people who already have a history of high blood pressure, it also appears more in patients using the drug to quit smoking. The FDA states, There is no clinical experience establishing the safety of Wellbutrin in patients with a recent history of myocardial infarction or unstable heart disease. Therefore, care should be exercised if it is used in these groups.
Adderall and other stimulants have long been the source of debate due to their cardiovascular health implications. Common heart-related side effects of Adderall include hypertension and elevated heart rate. One study found that 3% of otherwise healthy adults experienced adverse cardiovascular effects, including severe high blood pressure, heart palpitation, or tachycardia when using Adderall. When combined with the dangers that Wellbutrin can pose to a patients heart health, the potentially negligible cardiovascular symptoms presented by Adderall can quickly become far more life-threatening. Taking Wellbutrin and Adderall together adds significant risk of long-term heart problems and sudden death by a heart attack.
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How The Intervention Might Work
Studies have demonstrated similar bioavailability for immediate, sustained and extendedrelease bupropion, but information about their efficacy and the occurrence of adverse effects is scarce. The spontaneous seizure rate reported in the general population is approximately 0.1% , whereby the incidence of a convulsion rises significantly at dosages higher than 450 mg per day, the highest recommended dose . Also, some people taking the drug have developed anxiety, some have developed headaches , and others have reported exacerbation of tic disorders . The potential increase in blood pressure is usually small and only of concern in those with marginal or high blood pressure. Bupropion shows little impact on weight and sexual function . Doserelated side effects are mediated via the catecholamines transmitters. The mechanism of idiosyncratic side effects is unknown.
Both bupropion and methylphenidate are dopamine and noradrenaline reuptake inhibitors at the presynapse. However, the reuptake inhibition is less strong for bupropion, as reflected by the half maximal inhibitory concentration , which is a measure of the effectiveness of a compound.
Wellbutrin Vs Adderall: Final Words
So to answer the question of Wellbutrin vs Adderall: they have some similarities, but theyre not the same, and which one you should take depends on what condition you need to treat.
Does Wellbutrin give you energy? Wellbutrin works to increase the levels of neurotransmitters like dopamine and norepinephrine in your brain, which can give some people a boost of energy.
But is Wellbutrin a stimulant like Adderall? No, Wellbutrin is technically classified as an antidepressant.
Comparing Wellbutrin vs Adderall is difficult because ultimately they are in different classes of drugs and have different purposes.
Its essential to know the difference between these medications and what they can be used to treat.
Medication isnt a one-size-fits-all solution, and your diagnosis or symptoms may change over time as well. When trying to find the right medication, sometimes its important to try different ones because things change.
A healthcare professional will both recommend and prescribe the right treatment option for you.
Conditions such as depression and ADHD arent one-size-fits-all issues they can be hyper-individualized and can happen simultaneously.
A great first step to take in treating depression or other issues is talking to someone which you can do by scheduling a telepsychiatry evaluation today.
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Elon Musk On Twitter Says Wellbutrin Should Be Taken Off Market Heres The Pushback
Tesla CEO Elon Musk, who has expressed plans to buy Twitter, got quite a response for a tweet on … Wellbutrin, an antidepressant medication.
Elon Musk is not a medical doctor. Hes not a psychiatrist or any other type of mental health professional. But on Friday, he expressed a very strong opinion about Wellbutrin, an anti-depressant medication, on Twitter. Yes, Twitter, that social media platform that he plans on buying for $44 billion, which is about $44 billion more than most people will ever have. Take a look at how Musk responded to a tweet from Netscape co-founder Marc Andreessen about a different medication Adderall:
As you can see, Andreessen had originally tweeted, Everyone thinks our present society was caused by social media. I’m wondering whether Adderall plus ubiquitous Google searches have bigger effects. Note that Andreessen, whos not a medical doctor or other mental health professional either, didnt specifically mention Wellbutrin but instead pasted a passage that mentioned Wellbutrin without specifying from where he got that passage. Nevertheless, Musk decided to throw in a well, how about Wellbutrin type of reply: Wellbutrin is way worse than Adderall imo. It should be taken off the market. Every time that drug has come up in conversation, someone at the table has a suicide or near suicide story.
He emphasized the need to increase access to ALL depression treatments in the rest of his thread:
Does Wellbutrin Enhance Adderall
Some people wonder if combining Wellbutrin and Adderall can increase the effects of each medication. While both drugs increase the neurotransmitters norepinephrine and dopamine, and both may be used to treat ADHD, theres no literature to show that Wellbutrin enhances your bodys response to Wellbutrin. In fact, experts say its a pairing you may want to avoid due to potential safety concerns.
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What Drugs Interact With Wellbutrin
Wellbutrin may interact with insulin, blood thinners, and asthma medications. Wellbutrin may also interact with many medications including heart or blood pressure medications, HIV or AIDS medications, seizure medications, other antidepressants, medicines to treat a psychiatric disorder, antibiotics, antihistamines that make you sleepy, bronchodilators, birth control pills or hormone replacement estrogens, bladder or urinary medications, diet pills, stimulants, ADHD medications, oraldiabetesmedication, medicines for nausea/vomiting/motion sickness, medications to treat or prevent malaria, medicines to treat Parkinson’s disease, medication for restless leg syndrome, medication for pituitary glandtumor, medicines used to prevent organtransplantrejection, narcotics, numbing medicines, steroids, theophylline, or ulcer or irritable bowel medications.
Does Wellbutrin Help You Focus
Wellbutrin is not indicated to treat symptoms of ADHD, such as the inability to focus. However, Wellbutrin is sometimes prescribed off-label for ADHD treatment. It may not be as effective as a stimulant for ADHD symptoms, but for certain patients who canât tolerate stimulants or have a history of abuse, Wellbutrin may be an appropriate option.
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Data Collection And Analysis
Two review authors independently screened records and extracted data using a data extraction sheet that we tested in a pilot study. We extracted all relevant data on study characteristics and results. We assessed risks of bias using the Cochrane ‘Risk of bias’ tool, and assessed the overall quality of evidence using the GRADE approach. We used a fixedeffect model to pool the results across studies.
Why Take Wellbutrin For Adhd
Although stimulants are the most effective treatment for ADHD, your doctor might prescribe a non-stimulant, second-line medication like Wellbutrin for a few reasons:
- Effectiveness: Not everyone who takes stimulant medication finds relief from their ADHD symptoms.
- History of medical conditions: Sometimes, an underlying medical condition makes the use of stimulant medications problematic. Such conditions include heart problems, sleep disorders, and psychiatric conditions such as substance use disorder and bipolar disorder.
- Tolerance: Some people do not tolerate stimulant medications and experience severe side effects.
Other non-stimulant medications for ADHD include Strattera and Catapres .
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Can I Use Wellbutrin Or Adderall With Alcohol
You should not combine Wellbutrin with alcoholâit can increase the likelihood of seizures. Consult your healthcare provider for advice on decreasing your alcohol use.
Using Adderall with alcohol can be very dangerous and can cause problems like lack of impulse control and accidents. The combination can make you unaware of how much you are drinking and can cause alcohol poisoning, with symptoms of nausea, vomiting, irregular heartbeat, seizures, and difficulty breathing.
Criteria For Considering Studies For This Review
Types of studies
Randomised controlled trials , including acute studies , as well as shortterm , mediumterm , and longterm studies .
Types of participants
Adults aged 18 years or older, diagnosed with ADHD according to formal, standardised diagnostic criteria Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision International Classification of Diseases, 10th Revision ). We included all ADHD subtypes. We did not exclude comorbid psychiatric conditions.
Types of interventions
Any formulation of bupropion , at any dose, compared with placebo. We did not exclude studies with adjuvant interventions if they were provided to both arms of the study.
Types of outcome measures
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